Promethazine and Codine Question

[Black_one]

Hi all me and a mate are sitting round the house with nothing to do we alredy smoked all our weed8o. I went through the cupboard and raided my meds. The best i can find is Phenergan 10mg tabs (9 total) and prodine forte Paracetamol 500mg codine phos 30mg (15) what is the best combo? I have heard that the phenergan is an opiate potentiator but after hours of searching can find no real info thx in advance from the both of us

[jasoncrest]

Hi all me and a mate are sitting round the house with nothing to do we alredy smoked all our weed8o. I went through the cupboard and raided my meds. The best i can find is Phenergan 10mg tabs (9 total) and prodine forte Paracetamol 500mg codine phos 30mg (15) what is the best combo? I have heard that the phenergan is an opiate potentiator but after hours of searching can find no real info thx in advance from the both of us

Phenergan (Promethazine) is a good and strong potentiator of Opiates. 25mg is a good dose (if you have no tolerance, it may even be a bit too much, and make you sleepy).

BUT Phenergan (Promethazine) inhibits the enzyme that converts Codeine to Morphine... (CYP2D6).

So if you take Phenergan to potentiate Codeine, take it once you feel the Codeine (~1 hour after taking it).
Take 250mg Codeine if you have no tolerance to Opiates.

(you can take 8 APAP/Codeine 500/30 pills without killing yourself, that makes 4 grams APAP, the max. safe daily dosage, and 240mg Codeine, but it still would be a better idea to do a Cold Water Extraction)

[jasoncrest]

Shit, i didn't know that... Good to know, thanks! (I'have probably wasted a lot of codeine by taking the phenergan at the same time)

As it is said in a few other threads on Codeine, the effects of Codeine seem to be caused by Codeine-6-Glucuronide, not Morphine....
(from 0 to 10% of Codeine are converted to Morphine by CYP2D6; 80% of Codeine are converted to Codeine-6-Glucuronide, which has an opiate-like effect...)

There is something on Pubmed saying that the analgesic effects of Codeine are due only to codeine-6-glucuronide; but I don't what causes the euphoric effects of Codeine... Morphine or Codeine-6-glucuronide?

[Opiatesrarely]

"There is something on Pubmed saying that the analgesic effects of Codeine are due only to codeine-6-glucuronide; but I don't what causes the euphoric effects of Codeine... Morphine or Codeine-6-glucuronide?"

does anyone know which one causes the euphoric effects?

also, i know that DpH inhibits CYP2D6, so will DpH cause more of the codeine to become C6G?