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static_mind
12-06-2009, 10:02
Iv seen excelent results from SSRI's from my friends that use it (all drug users) and Avanza.
Smyth
12-06-2009, 11:52
SSRIs are cancer.
Sturnam
13-06-2009, 00:19
I still think NMDA antagonists are the way to go. They exert their antidepressant effects in the first few hours of use, and then continue on. Problem is, they're all too much fun, so the government won't let us have them yet :p
PetersKeys
13-06-2009, 11:28
do you guys actually think 'anti-depressants' work? I think they are total and complete BS. The only real anti-depressants are all illegal, lol go figure.

they definately can help. It really all depends on finding the right combo. But once you find it they can really help. Bupropion has tremendously lessened my cravings for stimulants.
kfluxsake
22-06-2009, 18:15
Someone suggested Periactin (Cyproheptadine). Not a good idea as it's antiserotonergic.

Made me extremely depressed while taking it for sleep problems with escitalopram
macropsia
22-06-2009, 19:43
Someone suggested Periactin (Cyproheptadine). Not a good idea as it's antiserotonergic.

The 5-ht2a antagonism might be an issue in some, but 5-ht2c antagonism has disinhibiting effects on certain parts of the brain and is linked with some antidepressant efficacy.
vecktor
22-06-2009, 20:33
is Cyproheptadine still widely used? it has some interesting effects in rats and other critters on the insulin producing beta cells.
LabRatNW
22-06-2009, 23:30
SSRIs are cancer.

Agreed. They're horribly (physically) addictive and cause nasty withdrawals. But they do work well for some people.
kfluxsake
23-06-2009, 18:48
THANKING ANY MOD WHO CAN BRING THIS TO ATTN OF REIMANN ZETA. UNABLE TO PM

Hi,

I am assuming you are in the UK -I read in your posts about how you take dexedrine. How can I ask did you manage that one? I've had TRD for about 7 years, been on 20+ medications+ currently doing 'ok' on a cocktail of high-dose bupropion, effexor and clonazepam.

The benefits are modest. I'm sure since d-amphetamines are not genuine antidepressants, they rarely play the position as 'workhorses' of theraputic regimens, but I am intrigued to know how they affect your daily mood/coping abilities. And also whether tolerance/ receptor downregulation compromise long-term effctiveness?

I am looking more and more into pstims for augmentation (I did try modafinil once with some success, but found it had a bad cumulative effect of sleep and its positive effects on mood disappeared after a month)

Apologies for the mini-essay. Questions answerable at your convenience. Thanks very much,

Kflux
sebukab
24-06-2009, 06:33
Assuming no abuse, is low dose tramadol a viable antidepressant?
Tsukasa
24-06-2009, 06:44
^ Definately. Best AD i've ever encountered. Been on it for a very long time and still works great.
mitragyna
30-06-2009, 09:14
I still think NMDA antagonists are the way to go. They exert their antidepressant effects in the first few hours of use, and then continue on. Problem is, they're all too much fun, so the government won't let us have them yet :p

Yeah, I've always wanted to try Memantine. I could be wrong, but I don't think there is a whole lot of abuse potential with it. Maybe I'll ask my Psychiatrist if he'd prescribe it as an add-on to the Parnate, Suboxone, and Lyrica I'm currently taking. I don't think that it would be a problem with an MAOI.
mitragyna
30-06-2009, 09:17
Assuming no abuse, is low dose tramadol a viable antidepressant?
IMO, Absolutely!
Hammilton
30-06-2009, 16:44
^ Definately. Best AD i've ever encountered. Been on it for a very long time and still works great.

Yeah, but you just admitted to being addicted to it and said that you planned on living only a short while longer in the same post. Not exactly a vote of confidence, huh?
Smyth
01-07-2009, 21:55
Assuming no abuse, is low dose tramadol a viable antidepressant?

Please consider reading the following document:

http://jop.sagepub.com/cgi/content/abstract/18/3/404
Hammilton
02-07-2009, 00:09
I read that one looking for info about this actually. I wish they would have looked at behavioral measures too. They may be flawed, but they're better than nothing. The measures they look at don't seem useful to me for looking for antidepressant effects.
permastoned
02-07-2009, 00:20
Agreed. However Hammilton, I think we both know that when the temperature in your rectum is raised, you must be happy because I would be inside of you.

I can't think of any proper reason as to why tramadol would be any better an antidepressant than venlafaxine, as the opioid component is so weak that I personally can't even feel it (unfortunately huge tolerance), UNLESS, it has some other separate mechanism of action such as delta opioid agonism etc.