For those who snort oxycodone...

[sebukab]

Has anyone who disagrees with the BA statistics ever tried oxymorphone Nasally vs Orally? Quite a huge difference there.

[menaces]

and theres a rush, which you don't get by taking it orally.

There is? Really? So when this chemical enters your blood stream, wether by IV, or Snorting, or Oral Admin, there are different sensations?

See I dont believe that, because i've done oxycodone, all three ways, hundrends of times.

And the feeling of all three are identical, yes snorting is faster, but its the same type of onset as eating is, and iving just makes you feel all the goody opioidness instantly.

So when people report a certain rush that you can't get by eating it, think twice. It's all in your head, maybe because you guys like being ritualistic, but honestly, try it all three ways and HONESTLY describe the feeling, and remember, from a person who gets off on oxy atleast 3 times a day everyday for the past 6 years, eating it has always been my favorite.

ps. and by the way, all you kids claiming you have a high tolerance, and you snort a whole 80mg, please think again.

My tolerance currently is at about 450mg by mouth, now thats a high tolerance.

[menaces]

I've said this a hundred times, but I guess I'll say it once more: BA % NUMBERS MEAN NOTHING.

Choosing the best ROA depends on a plethora of factors, including the amount of powder being insufflated (the biggest factor), your individual metabolism, and personal preference.

Published BA numbers are complete nonsense, and anyone who blindly buys into them needs to go to college and take a few statistics classes. For starters, snorting 10mg of powder is HUGELY different that snorting 100mg of powder. If you snort 10mg, likely all 10mg will be absorbed intranasally. But if you snort 100mg, about 90% will be absorbed by your lungs and GI, as your sinuses pack fairly quickly with powder.

And just a few figures from my own measurements:
- An OC80 weighs 270mg
- An adderall 10mg IR weighs 240mg
- An adderall 30mg XR weighs 235mg

So basically, if you snort a whole pill of any pharm, it's going to be a MOUNTAIN of powder, and almost none of it will be absorbed intranasally. Most of it ends up in your stomach. So that alone shows how the great "Oral vs. Nasal BA absorption" statistical figures are bullshit.

The second important factor is based on an individual's specific hepatic function. Perhaps they have high 3Ax function which creates noroxycodone and low 2D6 function which creates oxymorphone. Or vice versa. What I'm getting at is maybe the 1st pass metabolism is a good thing, because it produces higher levels of oxymorphone. Conversely, it could create other less desirable metabolites. So you can snort or eat your drug, depending on if the 1st pass metabolism is a beneficial or detrimental phenomenon.

Lastly, different MOAs are a matter of preference. Some people have needle fetishes, some have smoking fetishes, snorting fetishes, plugging, etc. etc. That makes a HUGE difference on the pleasure induced by consuming drugs. Just look at the "crack epidemic" of the '80s; people started turning the water soluble, highly absorbent cocaine HCL into a non-absorbent freebase, SIMPLY because the act of smoking is so much more enjoyable. The onset is slightly quicker, and the smoking aspect is enjoyable, therefore we had an explosion of people smoking crack, despite the fact that it is FAR less efficient than snorting cocaine (as much of the crack is destroyed by heat during the smoking process).

And one more thing, published BA percentages are based solely on measured blood serum levels after long time intervals, which ignores the fact that snorting produces much higher levels much sooner vs. oral consumption.


CLIFFS:

1. Bioavailability numbers mean nothing
2. Figure out for yourself what your own body prefers
3. Snorting bypasses the 1st pass metabolic response
4. Snorting creates a higher high for a shorter duration. No surprise there
5. When you snort oxy, MOST of it goes into your stomach anyway, so it's almost the same as eating it. It's just that you've also got some in your sinuses that will kick in sooner.


Empiricism >>>>>>>> random published bullshit



OC80 weighs exactly 300mg. not 270mg

[JunkieStatus]

ps. and by the way, all you kids claiming you have a high tolerance, and you snort a whole 80mg, please think again.

My tolerance currently is at about 450mg by mouth, now thats a high tolerance.

Who here was claiming they had a high tolerance, it may be a high tolerance to them personally but not to others..450mg by mouth okay, yes you do have a high tolerance than the general population..I just despise people who brag about their tolerance there really is no point..But what I do think is that this thread should be closed because the date on this thread is really old what needed to be said was said and alot of irrelevant information is popping up I've seen alot of "which way is better to administer oxycodone or oxycontin" threads around here..I think an admin should close this thread..Where is William1985 "Unknown" when you need him he likes to close things down

[skoat]

the date on this thread is really old what needed to be said was said and alot of irrelevant information is popping up

True.

[macbrown21]

I usually snort 80 or 100mg with benadry and xanaxl. That gives me a nod sometimes. I just took a 10 day break. Today when my internet shipment came I snort about 60mg with 200mg of tagamet, 50mg of benadryl and 1.2mg of xanax. I have got the most intense nod ever right now. That tagamet really really did someting. I usually look pretty sober on oxy and today me mom said you look copletely wasted lol. This is taking me like like 20 minutes ti type. Wooow tagamet. feels like I took 200mg of oxy, Wonder if it was the week off or the tagamet. anyone have any ideas or similar results, please share.
I'm so happy i didnt snort the whole 80 mighta been in trouble...nod....nod......nod lol. Like 40 minutes btw.
Later

I'm gpnna have to look at this 2morrow to aee if tmaskes sebse at akkp(on HOU

Yea I was in such a nod that is barely legible adding the tagamet made an unreal difference. (I dont think my tolerance could have dropped so much in just ten days) I still have a nod and I ate dinner and hada coke wow.

[Fail Fighter]

OC80 weighs exactly 300mg. not 270mg


I weighed 10 pills and it weighed 2.6g. So I assumed 260mg each. I wish I had a milligram scale, but that's the best I can do. Other people on this forum have confirmed ~270mg per pill

[Oxyrisin2]

For me snorting 40mg of OC gives me the same high with a nice rush, as eating 40mg.

^^I totally agree.
Plus I don't know why people have to keep arguing that snorting is a waste over oral. Who gives a fuck.
If I buy the OXY its my fucking Oxy. and if I want to waste it by snorting it or crushing it up and toss it off a brige so be it. Do you think I give a fuck what you think..Its my pill and its my ROA. So quit being nosy and leave my nose alone..:p
PEASE..%)

[jigsawpuzzlepiece]

Holy shit I am so dyslexic I saw this thread as "For those who smoke oxycodone..." saw that it was 3 pages, couldn't believe my eyes, came to respond "For those who smoke oxycodone: you're fucking retarded" but now I see it is I who am retarded ;)

As for the actual topic, there is a noticeable difference in the high from 20mg IR versus snorting 20mg IR, but you'd really have to be kind of experienced and looking for it to notice. Even with a high tolerance, I still prefered to snort some first to get things rolling then once I could calm down and maybe not be sick if I was in W/Ds previously I would start preparing oral doses to supplant that.

Like I said its not a big difference in potency, the main reason I like taking it orally is that it lasts longer.

[Fail Fighter]

A lot of this is fetish related. My brother once told me that he snorted so much Adderall that all he had to do at one point was pinch off one nostril and inhale deeply (without inhaling any actual drugs) and he'd get a placebo rush. Just because his brain was programmed to derive pleasure from the act of snorting things.

Some people have snorting fetishes, some smoking, some needles... This is nothing new. The drug/pleasure association is based on dopamine release, and certainly this is related to ROA. I know I've seen IV users get all giddy at the sight of needles (whereas I personally get queezy and pass out). I'll admit, I've got a slight insufflation fetish myself. The pleasure is derived partly from the ROA act, not just the ingestion of mind-altering substances itself.

[Oxyrisin2]

But what I do think is that this thread should be closed because the date on this thread is really old what needed to be said was said and alot of irrelevant information is popping up I've seen alot of "which way is better to administer oxycodone or oxycontin" threads around here..I think an admin should close this thread..Where is William1985 "Unknown" when you need him he likes to close things down

^^If ya don't like the thread and don't want to contribute to it, then don't click on it and move on.
Who wants to listen to you complain about a thread thats not up to your standards...

[opiate_hug]

im too lazy to crush up an oxy and snort it. ill chew the bastard but not snort it.:)

[bi9000]

im too lazy to crush up an oxy and snort it. ill chew the bastard but not snort it.:)


did you really need to bump this old of a thread to say that?

[sveets]

sometimes its just more enjoyable to snort them. Im aware its more effective to eat it, but i like snorting little lines every couple minutes because its more enjoyable than just eating it. I used to never snort but now that my tolerence has gotten higher i can snort a 30mg roxy and get a good high for a couple hours opposed to a weaker longer lasting high from eating. I think that spreading it out into small lines works great because i let my nostrils clear so im absorbing more. Some people are dumb and blow a whole 30 in one line because they are hardcore...

[vonchampz]

Why did this thread get resurrected??? Yes we all know the oral route of administration of oxycodone has a higher bioavailability. It doesn't mean it's wrong to snort it. There is more of a rush and many people prefer that. The bioavailability of oxycodone through IV injection is 100% but that doesn't mean that we should endorse this or that it is a better ROA.... What's the point of brining this thread back. There are millions upon millions of bioavailability threads and ROA threads for oxycodone and other drugs/pharms in BDD. Lets move this shit ova' there!!!! =D

[stuckinaloop]

Even though this thread is fucknig old as shit I am gonna say.

Regardless of scientific facts...I just feel better sniffing it.

I need instant gratification.

The only time that I ever felt like I wasn't wasting oc's by eating them was when I first ever started and swalling one 30mg oxy ir would fuck me up the whole night.

Even though bioavailability is soo much higher oral...I feel much more fucked up sniffing 2 80s then them chewed up and eaten.

To each their own...oral has a better ba but sniffing is by no means a waste.

Also, I know there are a lot of people on here..but I have never met someone in person who is addicted to opiates and eats their oxycodone as their primary roa.

Plus you get a drip too which excess oxy that drips down is obsorbed in stomach...so you are eatin a little.

Some people are dumb and blow a whole 30 in one line because they are hardcore...

You are right that spreading out small lines makes for better absorbtion..its obvious. But I honestly don't think it makes that big of a difference. With heroin its different, because anything that drips gets barely any BA in the stomach. It's got nothin to do with being hardcore. When I do oxy i never ever do a million little lines lol, it would take me an hour to sniff the whole dose. If I am sniffing 4 30's ill have 4 lines or less and never noticed much a difference..what am i gonna do 20 lines. I regularly used to sniff 90mg multiple times a day out a cvs pill crusher in 1 shot up your nose, and even that I still didn't notice too much of a difference (though you do get a good amt more drippin down to your stomach).

I would much rather sniff 90mg out of a pill crusher in 1 shot of powder up your nose then eat the same amt

Just my opinion..and yah noone is watchin me when I do this, not tryin to look hardcore n show off how much powder i can get up my nose

[Rexeh]

Some SQL Resident Evil / Silent Hill stuff going on here with this thread o0

someone forgot to put out the light... =)

*click*

-- Peace

[itsALLfake]

Let's talk about the oral bioavailabilty with someone with a liver disfunction... If you're me then snorting is a better way to go, cuz I never shot. If I don't let it chill sublingually and I just swallow it, I'm feeling a threshold kind of high.
I've been clean for two years though..I prefer living a good life. One that I can get up in the morning and feel good about myself without worrying where some green monster BS might be.

besides...I wonder where people get their numbers from...everyone's bodies can be radically different in the ammount of certain enzymes the liver and pancreas make that destroy compounds like opiates or anything else.

[Idi0tequ3]

i found the solution eat some, snort some, and plug some, all at the same time.. best of all worlds and you can all stop arguing over personal preference.