For those who snort oxycodone...

[ktx49]

i have posted this information before via reply to a previous thread, but it did not seem to be widely acknowledged or accepted....well, now i have found yet ANOTHER reliable site confirming what i had said; oxycodone HCL is absorbed less effectively when snorted.

for those of you who arent familiar with me, i used to abuse oxycodone on a regular basis(daily lol) for a couple of years...before i went onto methadone, i was using over 400mg of crushed oxy or oxy-IR at once to get high. before my tolerance got to that point, i did sometimes ingest my oxy by snorting some or all of it. however, when it got over the 200mg mark, i started noticing that it was seemingly not as strong when i snorted my dose verses taking it completely crushed orally. i thought it was in my head or the fact that the high amount of oxy i was needing required many more pills and therefore had alot more fillers/binders that were probally not water soluble and were clogging up my nose preventing full absorbtion of the oxy when snorted...maybe a combination of both lol.

then i finally came across a reputable source a while back that claimed oxycodone HCL was indeed absorbed more efficiently when taken ORALLY by a decent margin when compared to insufflation/snorting. i never got specific numbers but i just happened to stumble across the article on wikipedia about oxycodone and found some good figures that might be of interest to those who use oxy; especially insufflated. basically a good 20% minimum increase....

snorted=46-47% availability vs. oral=60-87% availability

see for yourself:
http://en.wikipedia.org/wiki/Oxycodone#Chemical_structure

i admit i am fairly suprised that it is that large of a difference. i always suspected oral was better but for the reasons stated above, i never could say for sure. now im glad i not only saved my nose the hassle/pain of snorting all that oxy, but also helped my wallet stay a little fatter by getting the most outta every pill.

so i hope some of you will take this information to heart and stop snorting your oxy if possible...i know some people just simply prefer the slightly quicker onset and feeling, but with a significant efficiency advantage taken orally, it may convince some of you to just crush and swallow your OCs/oxy/percs/roxis/whatever from now on.

http://en.wikipedia.org/wiki/Oxycodone#Chemical_structure

hope this helps,

-ktx49

[stirfry]

from the wiki article:
Oxycodone can be administered orally, intranasally, via intravenous/intramuscular/subcutaneous injection, or rectally. The bioavailability of intranasal administration averages between 46-47%, but can be as much as 75%. Oral oxycodone is the most efficient means of administration, having an absorbtion of 60-87%. Rectal administration yields the same results. Injecting oxycodone will result in a stronger effect, and quicker onset, with a bioavailability slightly higher than oral administration

now note where is says "Injecting oxycodone will result in a stronger effect, and quicker onset, with a bioavailability slightly higher than oral administration"

by definition, when a substance is injected the bioavailability is 100%. bioavailability is a reletive measure of drug effectiveness against injection. so basically what im tryin to say is that shit is wrong. wiki cant always be trusted as the gospel.

with that said, its still very possible that oxycodone is more efficient to eat then to snort, i have no clue.

[Pegasus]

^The figures aren't wrong, check out the bioavailability mega-thread stickied at the top of this page. The nasal bioavailability of oxycodone is listed at ~46% from a few different sources...

[funkee]

Rapidity of onset is what lures users who stray from IV use, to snorting.

[TokinDerrick]

and theres a rush, which you don't get by taking it orally.

[Voodoochild870]

Damn dude, ive always sniffed my oxys and roxies, next time I get some I'm chewing them bad boys.

[axl blaze]

thanks for the info ktx. you just proved why, in my day of doing oxys, that I would swear up and down to my friends that snorting them was possibly a waste and that the high just wasn't a good quality high compared towards eating them.

it's nice to have some proof next time this convo comes up :)

[sonic]

Thank you for starting a decent thread, but I don't see this information as absolute proof, although it could be accurate. All this means is that someone made that wiki entry and no one has disputed it yet. I don't always trust wikipedia for drug information.

I interpret the nasal availability of 46-47% to mean that is how much actually gets absorbed by your mucus membranes. If my interpretation is correct, that wouldn't count all the powder that ends up dripping down the back of your throat. It would be interesting to know about how much powder ends up getting clogged in your nose from an OC80 (on average). After I snort I usually irrigate my nose, and it doesn't seem like very much gets wasted.

It might be slightly more efficient to take oxycodone orally, but I'm not entirely convinced it is 20% more wasteful to snort oxy.

EDIT: One thing I have noticed about snorting oxycodone is that the high doesn't last as long as it does orally. This would explain why you might prefer to take it orally.

[TokinDerrick]

It might be slightly more efficient to take oxycodone orally, but I'm not entirely convinced it is 20% more wasteful to snort oxy.



same, anyone thats done both will agree that its not a HUGE difference, other than the duration and the onset.

[Pegasus]

I think the reason behind the similar effects is that bioavailability does not take peak plasma concentrations and time into account...

[Boiling in Acid]

see this lol:

''Also, chronic medical use has been shown to slightly decrease testosterone levels in men. Misuse or long-term medical use of the drug can cause temporary impotence as well as a significant prostate enlargement in men.''

i never had the pleasure of it anyway :) haha

[TokinDerrick]

I'll agreen hat it causes temporary impotence.

on oxy, I think my dick actually shrinks, but goes normal when I'm not on it.

[ktx49]

yea i realize that wiki is not the end all be all of information and stuff, but it DOES go to show that i wasnt making up my previous statements about snorting oxy being less effecient than orally....

again, if you do want to find some more information on this, do a search, as a poster above me said, its listed at other sources very close to the figures i posted.....

and no where did they say that IV was not 100% efficient just that it WAS more efficient than oral use, which happens to be true.

the article is accurate and so are the figures, but i know some people will always insist that its not or that its only slightly less efficient(which IS very likely due to the fact that a huge pile of powder from a crushed pill whether its an OC or oxy-IR, will indeed, make its way to the stomach eventually...).

like axl blaze said, i would ALWAYS swear when i got to the point of very large doses that i was not getting the same high when snorting my oxy compared to my usual route of taking it orally on a completely empty stomach with a glass of water....i think this was due to the fact that not only was it less efficient when snorted, but much of the oxy DID make its way to the stomach but only about 30-45 minutes AFTER insufflating it....therefore it was not hitting me all at once like it did when i shoved a huge amount of oxy into my stomach in one or two gulps....

please please please...for those of you who like to snort your oxy, fine, i have NOTHING against it, but just one time try taking it orally, completely crushed all at once on a empty stomach(no food or calorie-heavy drinks like soda for ATLEAST 4-5 hours), and tell me you dont get a much more intense high along with a STRONG "rush".
i know ur laughing when i say the word rush with oral oxy, but just try it like i said above....its not a rush in the since of an IV dose or anything, but its certainly as good if not BETTER than snorting it since no matter HOW quick you can manage to snort your pile of oxy, it will never ever hit you all at once like it will when properly ingested orally.

please believe me about this, i spent over 12grand on oxy in less than a year and used opiates daily(mostly oxy) for atleast 2 years straight!
i do not benefit from giving anyone false information...i just truly believe that many of you who usually snort your oxy, especially if its a large dose, will greatly appreciate this information and the experience when taken the proper way IMO, which is orally!!

thanks again guys and if you truly want more sources showing these figures on insufflation vs. oral ingestion i will find them again and post.

later
-ktx49

P.S.
PLEASE TRY MY ORAL METHOD I TYPED ABOVE HERE JUST ONE TIME...IF IT DOESNT HIT YOU HARDER AND "BETTER" THAN A SNORTED DOSE ATLEAST YOU GAVE IT A SHOT...THERES REALLY NOTHING TO LOSE!!! lol sorry for yelling i just feel very strongly about this subject and i feel that people always assume snorting will hit you "harder" and "quicker"...i can agree that it may sometimes kick in quicker when snorted but certainly it DOES NOT produce a better "rush"; atleast in my very experienced opinion!

[AphexAcid93]

I always enjoyed railing a couple of pills, after I'd munched a few. But just snorting it, alone...is a waste, IMO.

[ellua]

I always enjoyed railing a couple of pills, after I'd munched a few. But just snorting it, alone...is a waste, IMO.

ditto. if i rail it, effects seem to last only for a few minutes and aren't any more enjoyable anyway.

[Crunk_Cracker]

For me snorting 40mg of OC gives me the same high with a nice rush, as eating 40mg.

[ktx49]

^lol i agree too...

strangely, that was really the only way i did enjoy snorting any of my oxy....

so near my peak of tolerance, id have to take 4 crushed OC 80s and then while waiting for it to kick in orally, id sometimes snort a half an 80 or a whole one....

that was the only time i got any real results when snorted....

and i completely agree, i could snort 5 80s(400mg) and it would be nothing compared to eating the same dose...really it sucked. and snorting a generic was 10X worse so i'd NEVER ever consider insufflation unless it was an ABG(watson generic) or the normal purdues

[enoughorangejuice?]

same, anyone thats done both will agree that its not a HUGE difference, other than the duration and the onset.


Agreed. People aren't taking into account the drip or snorting water to wash it down so to speak. I'd say insuffilating lasts for me around 3-3.5 hours and a nicer rush than oral which lasts closer to 4 hours and feels slightly stronger but with much less of a rush, which is why I rail them unless the gel up, but I have some nice brand name OC 80's :) . I love them.

[pillsbury420]

For me snorting 40mg of OC gives me the same high with a nice rush, as eating 40mg.

I don't have extensive experience with snorting/eating OC's.. But I will say that there is a term called "placebo"...

Your brain will tell you that you are just as fucked up just because you believe it....

Logically, I could see more of a rush IF some of the OC was absorbed by your mucus membranes, however, I would think more would just trickle on down into your stomach at a slower rate..

Be careful, opiates are dangeros.

[Beans]

this thread is old dawg

[OverDriven]

Yep old thread. Not to mention, plugging it works better than either of the previously mentioned methods.

[enoughorangejuice?]

^ what about IV?

[chinacat311]

it depends on your definition of "better." IV will be an intense rush, but very short. plugged will give a decent rush but much longer duration..so its really a toss up.

[OverDriven]

^ what about IV?

When I said "previously mentioned" I meant insufflated and oral. Like the guy before me said, plugging vs. IV is up to the user.

[cashtothemoney]

46-47% intranasally according to that's poppycock...

vs.

60-87% orally

SOURCE: http://www.thatspoppycock.com/opiates/oxycodone.htm

[patte4dm]

I actually tried eating my oxy tonight instead of snorting it like Iv always done. I have a medium -high tolerence I might say for someone who uses only twice a week. I ate 60 mg's where I would normally snort all 60 at one time. The high didnt seem as strong and lasted only about 5-6 hours.

It seems like I get more out of it when I snort it. That was my first experience ever eating oxy. Im still not sure I believe this evidence yet. When you snort it some still gets in your stomach so I dont know. I may still stick to snorting.

[KBeesH]

When i dose oxy, I always dissolve half of my dose under my tongue and snort the other half..

[SFLraver]

I think they last longer when taken orally as well.

[dana1989]

Hey, i have been having pain in my upper neck for a day now and my friend suggested i try Oxy IR ....
She told me i could sniff a bit n it will help... but i didnt realise its more for the high rather then to get rid of the pain .... isnt that right?

I was wondering why people get some and how can you get some...
what are reasons people would actually need it for?

[raver2008]

Hey, i have been having pain in my upper neck for a day now and my friend suggested i try Oxy IR ....
She told me i could sniff a bit n it will help... but i didnt realise its more for the high rather then to get rid of the pain .... isnt that right?

I was wondering why people get some and how can you get some...
what are reasons people would actually need it for?

Unless your neck has some real medical problem not just being in temporary pain your not going to get a prescription from a doctor, and most likely noone is going to tell you what to say to try and get one if you dont need it, its against the rules on bluelight. If your in pain go tell the doctor and if he thinks you need something for the pain he'll give you something, but I wouldnt get your hopes up for oxys unless its a real injury

[PillPoppingAnimal]

Damn dude, ive always sniffed my oxys and roxies, next time I get some I'm chewing them bad boys.

u don t need to chew wroxies, i just pop em

they are IRs , instand release

contin is ER, guess what is stands for, no not extra, no not easy, no, guess

[PillPoppingAnimal]

dana 1989, if u have real pain, dont sniff, eat it

more of the drug gets absorbed, look into BA (bio-availability). Taking it orally vs. snorting has increased absorption, resulting in increased pain relief (vs. snorting), and a better chance of achieving euphoria.

[SRV RULES]

For me it lasts longer when take orally!

[Fail Fighter]

I've said this a hundred times, but I guess I'll say it once more: BA % NUMBERS MEAN NOTHING.

Choosing the best ROA depends on a plethora of factors, including the amount of powder being insufflated (the biggest factor), your individual metabolism, and personal preference.

Published BA numbers are complete nonsense, and anyone who blindly buys into them needs to go to college and take a few statistics classes. For starters, snorting 10mg of powder is HUGELY different that snorting 100mg of powder. If you snort 10mg, likely all 10mg will be absorbed intranasally. But if you snort 100mg, about 90% will be absorbed by your lungs and GI, as your sinuses pack fairly quickly with powder.

And just a few figures from my own measurements:
- An OC80 weighs 270mg
- An adderall 10mg IR weighs 240mg
- An adderall 30mg XR weighs 235mg

So basically, if you snort a whole pill of any pharm, it's going to be a MOUNTAIN of powder, and almost none of it will be absorbed intranasally. Most of it ends up in your stomach. So that alone shows how the great "Oral vs. Nasal BA absorption" statistical figures are bullshit.

The second important factor is based on an individual's specific hepatic function. Perhaps they have high 3Ax function which creates noroxycodone and low 2D6 function which creates oxymorphone. Or vice versa. What I'm getting at is maybe the 1st pass metabolism is a good thing, because it produces higher levels of oxymorphone. Conversely, it could create other less desirable metabolites. So you can snort or eat your drug, depending on if the 1st pass metabolism is a beneficial or detrimental phenomenon.

Lastly, different MOAs are a matter of preference. Some people have needle fetishes, some have smoking fetishes, snorting fetishes, plugging, etc. etc. That makes a HUGE difference on the pleasure induced by consuming drugs. Just look at the "crack epidemic" of the '80s; people started turning the water soluble, highly absorbent cocaine HCL into a non-absorbent freebase, SIMPLY because the act of smoking is so much more enjoyable. The onset is slightly quicker, and the smoking aspect is enjoyable, therefore we had an explosion of people smoking crack, despite the fact that it is FAR less efficient than snorting cocaine (as much of the crack is destroyed by heat during the smoking process).

And one more thing, published BA percentages are based solely on measured blood serum levels after long time intervals, which ignores the fact that snorting produces much higher levels much sooner vs. oral consumption.


CLIFFS:

1. Bioavailability numbers mean nothing
2. Figure out for yourself what your own body prefers
3. Snorting bypasses the 1st pass metabolic response
4. Snorting creates a higher high for a shorter duration. No surprise there
5. When you snort oxy, MOST of it goes into your stomach anyway, so it's almost the same as eating it. It's just that you've also got some in your sinuses that will kick in sooner.


Empiricism >>>>>>>> random published bullshit

[Fail Fighter]

The most important reason BY FAR as to why BA numbers are irrelevant is that they are calculated in regards to consuming PURE drugs. That is NOT the same as snorting pills.

Published intranasal BA figures for oxycodone are usually achieved by administering a drop or two (or a mist) of oxycodone solution into a subject's nose. Of COURSE it's all going to be absorbed intranasally!

But what do you think oxycontin is?? First of all, the act of snorting a powder is NOT the same as administering a solution. When you snort a powder, much of it goes straight into your lungs. Go figure. And second, oxycontin is 1 part active per 3.5 parts inactive. So 71% of the shit you're consuming is wax and filler. This filler is what blocks your mucosal membranes from absorbing the actives.

I can't stress enough how irrelevant BA numbers are. It drives me nuts how every other post on this forum spouts BA percentages when in reality it doesn't mean squat :!

[PillPoppingAnimal]

I've said this a hundred times, but I guess I'll say it once more: BA % NUMBERS MEAN NOTHING.

Choosing the best ROA depends on a plethora of factors, including the amount of powder being insufflated (the biggest factor), your individual metabolism, and personal preference.

Published BA numbers are complete nonsense, and anyone who blindly buys into them needs to go to college and take a few statistics classes. For starters, snorting 10mg of powder is HUGELY different that snorting 100mg of powder. If you snort 10mg, likely all 10mg will be absorbed intranasally. But if you snort 100mg, about 90% will be absorbed by your lungs and GI, as your sinuses pack fairly quickly with powder.

And just a few figures from my own measurements:
- An OC80 weighs 270mg
- An adderall 10mg IR weighs 240mg
- An adderall 30mg XR weighs 235mg

So basically, if you snort a whole pill of any pharm, it's going to be a MOUNTAIN of powder, and almost none of it will be absorbed intranasally. Most of it ends up in your stomach. So that alone shows how the great "Oral vs. Nasal BA absorption" statistical figures are bullshit.

The second important factor is based on an individual's specific hepatic function. Perhaps they have high 3Ax function which creates noroxycodone and low 2D6 function which creates oxymorphone. Or vice versa. What I'm getting at is maybe the 1st pass metabolism is a good thing, because it produces higher levels of oxymorphone. Conversely, it could create other less desirable metabolites. So you can snort or eat your drug, depending on if the 1st pass metabolism is a beneficial or detrimental phenomenon.

Lastly, different MOAs are a matter of preference. Some people have needle fetishes, some have smoking fetishes, snorting fetishes, plugging, etc. etc. That makes a HUGE difference on the pleasure induced by consuming drugs. Just look at the "crack epidemic" of the '80s; people started turning the water soluble, highly absorbent cocaine HCL into a non-absorbent freebase, SIMPLY because the act of smoking is so much more enjoyable. The onset is slightly quicker, and the smoking aspect is enjoyable, therefore we had an explosion of people smoking crack, despite the fact that it is FAR less efficient than snorting cocaine (as much of the crack is destroyed by heat during the smoking process).

And one more thing, published BA percentages are based solely on measured blood serum levels after long time intervals, which ignores the fact that snorting produces much higher levels much sooner vs. oral consumption.


CLIFFS:

1. Bioavailability numbers mean nothing
2. Figure out for yourself what your own body prefers
3. Snorting bypasses the 1st pass metabolic response
4. Snorting creates a higher high for a shorter duration. No surprise there
5. When you snort oxy, MOST of it goes into your stomach anyway, so it's almost the same as eating it. It's just that you've also got some in your sinuses that will kick in sooner.


Empiricism >>>>>>>> random published bullshit

The most important reason BY FAR as to why BA numbers are irrelevant is that they are calculated in regards to consuming PURE drugs. That is NOT the same as snorting pills.

Published intranasal BA figures for oxycodone are usually achieved by administering a drop or two (or a mist) of oxycodone solution into a subject's nose. Of COURSE it's all going to be absorbed intranasally!

But what do you think oxycontin is?? First of all, the act of snorting a powder is NOT the same as administering a solution. When you snort a powder, much of it goes straight into your lungs. Go figure. And second, oxycontin is 1 part active per 3.5 parts inactive. So 71% of the shit you're consuming is wax and filler. This filler is what blocks your mucosal membranes from absorbing the actives.

I can't stress enough how irrelevant BA numbers are. It drives me nuts how every other post on this forum spouts BA percentages when in reality it doesn't mean squat :!

ok iv never heard this...

so what do u think the best way to consume oxycodone is?

[wakeborder556]

Wow weird i thought something like that was going on. damn oral is the way to go!

[Fail Fighter]

so what do u think the best way to consume oxycodone is?


There is no "best way." That was the whole point of my rant.


I personally only snort it, but then again, I have no tolerance and only snort small doses. If I had a huge tolerance, I'd eat it, because when you snort a mountain of powder it all just goes into your lungs anyway, and I wouldn't want to have lungs full of pill junk.

[omgstfuplzttyl]

i like how he says "Another reliable source" and i see wikipedia in the url. any stunad from here coulda put that in there

[apconan]

When I don't have a lot, I always just parachute it because it goes further. If I have a lot I will also rail some.

[PillPoppingAnimal]

There is no "best way." That was the whole point of my rant.


I personally only snort it, but then again, I have no tolerance and only snort small doses. If I had a huge tolerance, I'd eat it, because when you snort a mountain of powder it all just goes into your lungs anyway, and I wouldn't want to have lungs full of pill junk.

are u actually smart in this situation or making this up cuz thats very interesting becuase im pretty sure everyone on this site thinks BA has a lot to do with the high...

how much "power" of an oxycontin would be "too much"? 40mgs?, 20mg , 80?

[Darkness2Light]

You realize the dates on a lot of these threads? Lot old shit flying up.

[Fail Fighter]

are u actually smart in this situation or making this up cuz thats very interesting becuase im pretty sure everyone on this site thinks BA has a lot to do with the high...

Well my I.Q. is 142, so I'd like to think I'm smart in all situations. As for the situation at hand, there are NO statistics on the BA of Oxycontin. Oxycontin is not Oxycodone.

It's a simply concept, yet no one on this forum seems to grasp it. The BA of PURE oxycodone is based on administering a low-dose solution (usually ~10mg via a few drops) intranasally. The BA is then based on blood serum levels, tested at varying time intervals. This has NOTHING to do with the BA of Oxycontin.


how much "powder" of an oxycontin would be "too much"? 40mgs?, 20mg , 80?

Test for yourself. I can't tell you the volume of your own sinus cavity. But me personally, I can snort about 15mg of oxycontin and then my nasal passages will be full. If I snort 20mg of oxycontin, there is a considerable amount that goes into my lungs, because at this point I have to struggle not to cough (and if I do, you'll see me cough up powder - that's the powder that was in my lungs).


Bottom line, BA % means nothing because we aren't talking about putting a few drops of oxycodone or amphetamine solution into our nostrils and letting it soak in; we're inhaling large mountains of pill powder via oxycontin, roxycodone, adderall, etc.

Huge, huge difference. And I've posted a certain statistic a million times before on this forum; they did a test on rats, where they sealed off their eyes, mouthes, and ears, then put them in a chamber filled with drug vapor. The study proved that the nasal passages (where ALL of the drug entered the rats) was only responsible for some 10% of the absorption; the rest was absorbed by the lungs and mostly the GI.


I'll put this into layman's terms for everyone: If the BA of drug X is 80% orally and 60% intranasally, and you snort a big pile of drug X, you're going to be absorbing at least 80% of it. As long as the drug enters your body, it will be absorbed by various mucosa in the nose, throat, lungs, stomach, etc.

[hydrouser]

[QUOTE=Fail Fighter;6992880]Well my I.Q. is 142, so I'd like to think I'm smart in all situations. As for the situation at hand, there are NO statistics on the BA of Oxycontin. Oxycontin is not Oxycodone.


Oxycontin is a extended release formulation of oxycodone. Someone tell me if I'm wrong.

[macbrown21]

I'd eat 60 then wait for it to kick in and snort the last 20 for a little rush. That always how i got most satisfied by an OC 80. Never stuck anything up the bum though, just doesnt seem pleasant to me.

[sonic]

Well, having an IQ of 142 is impressive. That certainly has most of us beat, but you're just making up the 10% figure when you're talking about what's getting absorbed by the nasal passages (mucus membranes). My guess is that it's more like 30% and another %30-50 percent gets absorbed by other organs, but I don't claim to know. It seems that since oxy is freely soluble in water and lipid soluble, more of it would be absorbed if you managed to hold the powder in your nasal cavity properly. 10% of the OC getting absorbed by your mucus membranes might be roughly accurate for taking a roxicodone 5mg tab or something low dose, an OC20 isn't ideal for snorting either. If you irrigate your nose 20-30 minutes after snorting and swallow the water or saline solution effectively cleaning your nasal passage of any powder, it should be nearly as effective as oral administration.
When you add possible increased peak plasma concentrations into the equation, it makes intra-nasal administration of oxycodone (especially in pills containing a high percentage of oxycodone) appealing IMHO.

Well my I.Q. is 142, so I'd like to think I'm smart in all situations. As for the situation at hand, there are NO statistics on the BA of Oxycontin. Oxycontin is not Oxycodone.

It's a simply concept, yet no one on this forum seems to grasp it. The BA of PURE oxycodone is based on administering a low-dose solution (usually ~10mg via a few drops) intranasally. The BA is then based on blood serum levels, tested at varying time intervals. This has NOTHING to do with the BA of Oxycontin.




Test for yourself. I can't tell you the volume of your own sinus cavity. But me personally, I can snort about 15mg of oxycontin and then my nasal passages will be full. If I snort 20mg of oxycontin, there is a considerable amount that goes into my lungs, because at this point I have to struggle not to cough (and if I do, you'll see me cough up powder - that's the powder that was in my lungs).


Bottom line, BA % means nothing because we aren't talking about putting a few drops of oxycodone or amphetamine solution into our nostrils and letting it soak in; we're inhaling large mountains of pill powder via oxycontin, roxycodone, adderall, etc.

Huge, huge difference. And I've posted a certain statistic a million times before on this forum; they did a test on rats, where they sealed off their eyes, mouthes, and ears, then put them in a chamber filled with drug vapor. The study proved that the nasal passages (where ALL of the drug entered the rats) was only responsible for some 10% of the absorption; the rest was absorbed by the lungs and mostly the GI.


I'll put this into layman's terms for everyone: If the BA of drug X is 80% orally and 60% intranasally, and you snort a big pile of drug X, you're going to be absorbing at least 80% of it. As long as the drug enters your body, it will be absorbed by various mucosa in the nose, throat, lungs, stomach, etc.


edit:

hydrouser: Yes, oxycontin is time release oxycodone. I believe the actual oxycodone is in hcl form just like with any other pill containing "pure" oxycodone. However, depending on the brand, crushing the pills is all you need to do in order to effectively break the time release. This is true with name brand pills at least. There are a few brands including teva that gel up when they come in contact with liquid. Those pills are more of a pain to deal with and aren't ideal for intra-nasal admin. They have the "dreaded wax matrix" (mscontin style). Dissolving the powder from a teva oc in a few ml alcohol and then evaporating it might work, but letting the solution soak for a few hours and then drinking it is a better idea.

[Sentimental]

I just snort it for a quick onset, even if the BA is lower and the high lasts shorter. And I love the whole ritual of snorting...Crushing, making lines, finding something good to snort out of, snorting it...It's great.

[InTheZone614]

I don't particularly enjoy the high I get when I eat or parachute oxy's.....it's too sedating for me
I like snorting them because it gives me an energy rush
to hell with bioavailability :)
to each their own

[Fail Fighter]

but you're just making up the 10% figure when you're talking about what's getting absorbed by the nasal passages (mucus membranes). My guess is that it's more like 30% and another %30-50 percent gets absorbed by other organs, but I don't claim to know.


"It is observed therefore, that lung, nasal and GI absorption accounted for 24.2, 12.5 and 63.3% of the total fluorescein absorption, respectively, following nose-only exposure of 3.7-µm aerosols."

http://www.springerlink.com/content/k7p803dbjbm1apqu/


The study used fluorescein, which, as it sounds, is just a dye. The study was basically showing that after intranasal administration of drug X, only 12.5% ended up being absorbed by the sinuses. This is a much smaller amount than I think anyone realizes. And as for Oxycontin, with only one in four parts being active substance, that's a 3/4 chance that the actual matter resting against the mucosa will be inert, no matter how finely you crush the powder.

[JunkieStatus]

There seems to not be much talk about rectal administration of "oxycontin" I know you guys were talking about "oxycodone" in the beginning, but I'm curious to see what you guys have to say about the no so much used route of taking oxycontin rectally... I was wondering what Sonic or Sixpartseven or anyone who has credible information about rectal administration with oxycontin..The only somewhat interesting information I read was
http://www.erowid.org/experiences/exp.php?ID=26458
There was information I found in there somewhat worth reading but I would like to find out specifics about rectal administration of oxycontin and effects..If any of you guys have articles/information about this please post them it would be greatly appreciated..