How to accurately dose alprazolam powder?

[ziddy]

Apologies are made for the previous thread that was deleted. There was never any intent of distribution of any controlled substances. Any preparation referred to in this thread is intended for use by a single person. It does not seem reasonable that this thread be deleted as it is created in the interest of harm reduction (avoiding excessively high doses, etc.).

There is alprazolam powder, assumed to be pure. There are also a milligram-precision scale (Acculab VIC-123), gelatin capsules with a ~0.6mL capacity, and 95% EtOH. It is desired that a dose of ~2-3mg be transferred into the capsule to, ideally, a +- 0.2mg precision. A solution of alprazolam in EtOH of known concentration can be readily prepared, but it is not known how an aliquot of a such solution to yield the desired amount might be effectively transferred into the capsule. Need the aliquot be stored in conditions of light and heat (a windowsill, perhaps), so as to allow the EtOH to evaporate and leave the alprazolam behind? How might the small amount of powder then be completely transferred into the capsule, without loss of product?

This is a simple question really, and this thread perhaps is better suited in another forum. It is to be stressed that the intent is to measure accurate doses of this potent substance for personal use. There is present such a small quantity of this powder that even if its possessor (who has never visited or been a member of this forum) desired to distribute it, there would be a negative profit.

It is also inquired as to how a pipette might be used to quantitatively transfer liquid without a bulb.

[The Monkey Mantra]

Look... this may be a really fucked up way to respond, but I recommend you do NOT mess with alprazolam powder. I thought I had my dosage right...

I don't even remember getting in my car. I don't remember a fucking thing. I lost three liters of blood internally and now I don't have a spleen. Missed two quarters, but after friday, I'm graduating with honors in Biochemistry!

Yeah, sure, do the liquid dosing. I just... recommend against every fucking with this stuff. It's too dangerous. If you get a triple dose of some RC, yeah, you'll trip fierce, but this is an *entirely* different animal.

Just my two cents about harm reduction. Be safe!

[Carsick]

Plenty of people have handled alpraz powder without needing medical treatment (or getting arrested)
Plenty of people have also failed at both with just pills.

Ok, powder takes more effort to get right, but with care isn't that hard.

[UnfortunateSquid]

Dissolve it into solvent at 1mg/ml.

Keep solvent in suitable container, somewhere dark/cool if possible.

Stir the solution vigorously before each administration, administer dose with a graduated dropper.

Don't take handfuls of capsules out with you, you'll just neck them.

If you can't handle the above points, bin the lot.

[The Monkey Mantra]

Originally Posted by UnfortunateSquid

Don't take handfuls of capsules out with you, you'll just neck them.

My belief, actually, is that this is what happened to me. I only took one, but when my parents checked the stash, all four were gone. In my amnesic state I must have taken the rest. I don't even LIKE xanax!!!

Look, I'm a moron. There's no argument there. This subject just gives me the willies. Please don't take my caution as an indication that it is not possible for an intelligent, informed adult to handle this stuff safely. I make no assumptions about your capabilities or those of anyone else! For me, however, I thought of myself as just such an adult and, by strange chance, made a horrible mistake.

-Greg

[Carsick]

There's a lesson to be learnt from your experience. Don't make capsules of powder when you're talking about 2mg being quite a lot.
Liquid measurement really is the way.

[wungchow]

When I took too much aplrazolam powder I always just fell asleep.

I didn't have a scale, I would judge the dose by the amount of bitter taste in my mouth. I would moisten a fingertip, get a tiny pinhead-sized blot of powder on it, then lick off the powder. If my mouth got overpoweringly bitter then I knew I ate too much.

[ziddy]

Why are replies to a scientific question asked in the second person? Perhaps the questions were a bit more detailed than is necessary, but the actual powdered solid involved is irrelevant. The question is also asked for compounds in which the dose range is 10-20mg. Well known are the amnestic properties of benzos. On multiple occasions there was observed a man that was careless and ate an excessive amount of powder (mass unknown). He would be dazed for several hours, but others would prevent him from reckless behavior.

That being said, there are many advantages to the capsule form. If there is need of acute anxiolysis, be its origin a panic attack or an overwhelming psychedelic experience, it is most certainly quicker and easier to swallow a capsule with a premeasured dose than to fool with a dropper and bottle of liquid (if one's hands are shaking violently, it'd be quite difficult to perform such a motor task). Additionally, capsules allow one to carry only one dose, thus precluding the possibility of amnestically, compulsively redosing.

Also sought is a resource listing the solubilities of various RCs and other chemicals in typical solvents.

[Smurfeh]

Originally Posted by ziddy

That being said, there are many advantages to the capsule form. If there is need of acute anxiolysis, be its origin a panic attack or an overwhelming psychedelic experience, it is most certainly quicker and easier to swallow a capsule with a premeasured dose than to fool with a dropper and bottle of liquid (if one's hands are shaking violently, it'd be quite difficult to perform such a motor task). Additionally, capsules allow one to carry only one dose, thus precluding the possibility of amnestically, compulsively redosing.

When trying to calm someone down having a bad trip trying to get them to swallow a pill (let alone if they can in their state) could be much easier said than done. If you're the one having a bad trip capsules make sense but easy access to more than needed could get you into trouble.

[jond2005]

can the same methods be done for diazepam powder as well? its soluble in alcohol too right?

[johanneschimpo]

yes

[fastandbulbous]

Originally Posted by wungchow

When I took too much aplrazolam powder I always just fell asleep.

I didn't have a scale, I would judge the dose by the amount of bitter taste in my mouth. I would moisten a fingertip, get a tiny pinhead-sized blot of powder on it, then lick off the powder. If my mouth got overpoweringly bitter then I knew I ate too much.

I am lost for words as to the stupidity of the above, esp the bit highlighted, when dealing with a drug active in the microgram range. It's that approach that makes threads like the one about safety in using RCs, with specific reference to opiate RC, a chilling prophecy of disaster just waiting to happen (CNS depressants aren't that much less dangerous, not because of toxicity, more because of the risk of indulging in dangerous behaviour)

[fastandbulbous]

That being said, there are many advantages to the capsule form. If there is need of acute anxiolysis, be its origin a panic attack or an overwhelming psychedelic experience, it is most certainly quicker and easier to swallow a capsule with a premeasured dose than to fool with a dropper and bottle of liquid

That's where having a premeasured dose of solution in a small bottle along with a syringe (no needles) is the best method. Rectal administration of a benzo in a 10% alcoholic solution acts with a minute or two; by having just a single dose in the small bottle, it does away with the potential stupidity of multiple redosing. Diazepam for vet treatment of grand mal seizures is abailable as a microenema because it acts so fast but doesn't carry the risk involved with injecting benzos. 2mg of alprazolam in 2ml is all the dose you'd need unless you'd indulged in the utterly foolish dosing involved with thumbprinting etc

[kakti]

A friend of mine had an extremely hard time getting alprazolam powder to dissolve in 80 proof whiskey. He found the best way to measure was using a known amount of distilled water and slowly lowering the pH until it all went into solution. Use a syringe going down to 1/10ths of mL for measurement.

[BilZ0r]

^ Yeah, you're not going to get alprazolam, or pretty much any benzo that isn't midazolam to dissolve in anything below about 70% alcohol. Infact, lorazepam doesn't dissolve in pure alcohol, at least in my hands.

Oh and FnB, if you're having a hard time getting your hard tripping amigo to eat a pill, imagine trying to force a syringe up his ass.

[Dondante]

Here’s how I did it:

A 20 mg/mL solution of alprazolam was prepared in 100% ethanol. Shaking and a small amount of heat were required to get it into solution. At first, I was unsure that it would dissolve, but 4 hours later I noticed it had all gone into solution.

I used a 100 microliter pipette (accurate to 0.001 mL ... available on Ebay) to transfer the solution into gelatin caps. Then I let the EtOH evaporate and was left with whatever dose was desired, accurate to nearly +/- 0.01 mg. I used this method for doses between 0.25 and 1.0 mg with no problems. BTW, gel caps are a must because the taste is awful.

Lastly, I must say that benzos are best used sparingly. Minor withdrawl symptoms can manifest even after daily dosing of only 0.25 mg. I use them occasionally at 0.25 or 0.50 mg to get to sleep and never more than 2 nights in a row.

[ziddy]

Are you certain it was 100% EtOH? Ethanol forms an azeotrope with water such that fractional distillation cannot increase the concentration beyond 95.6%. Drying agents such as calcium oxide can be used to dry it further, but supposedly such ethanol is extremely expensive. Also, as far as I know, ethanol is hygroscopic enough such that exposure of pure substance to air would result in forming the azeotrope.

Does addition of solution to the gelcaps damage them in any way? Is true 100% EtOH needed?

[fastandbulbous]

Oh and FnB, if you're having a hard time getting your hard tripping amigo to eat a pill, imagine trying to force a syringe up his ass.

You sit on him & arse rape him with a syringe! Seriously though, I didn't consider the prospect of a person not wanting to end a train wreck of a trip (for whatever reason) so I suppose if the person is that far gone it'll be difficult to do anything other than call in medical intervention

[ziddy]

This is interesting: XANAX BLOTTER PAPER IN BARTLESVILLE, OKLAHOMA

http://www.usdoj.gov/dea/programs/fo...08/mg0508.html

Originally Posted by fastandbulbous

You sit on him & arse rape him with a syringe! Seriously though, I didn't consider the prospect of a person not wanting to end a train wreck of a trip (for whatever reason) so I suppose if the person is that far gone it'll be difficult to do anything other than call in medical intervention

Messianic ideation could most definitely cause someone to not want to end a trip.