Abilify + Recreational Drugs

**kittyinthedark** · 30-09-2005 04:56

I was wondering if anyone knew what the interaction between Abilify (aripiprazole) and some common recreational drugs might be (ecstasy, shrooms, acid, etc). I'm having difficulty sorting through all the information online. I know it affects dopamine, but i've read that it's both a partial agonist and partial antagonist (both??) and that it works differently at different doses. Lord knows I'm not far enough along in my studies of neuroscience to have a clue, so anyone else out there got one??

**~~sickpuppy~~** · 30-09-2005 05:05

Abilify is one of those new anti-psychotics.(WTF are you doing with those anyway?)so I don't know a hell of a lot about it yet.I know it's supposed to have less side-effects than similar drugs.Let me check with my friend,he's a pharmacist and see he thinks.

**kittyinthedark** · 05-10-2005 06:12

*bump* anyone?

**CRexlz** · 22-12-2005 18:43

*Bump*

Thanks

**wheelah** · 04-01-2006 09:21

bumptiy bump bump
im typing at a weird angle a am take abilify daily along with some recreational drugs
i'm on doc and adderall today
bump bump bump

**rocklobster** · 04-01-2006 16:24

As far as I can tell, it's a partial agonist of dopamine and serotonin receptors, so it would seem that it would lessen the recreational effects of coke, meth, ecstacy, etc.

**halfoz** · 05-01-2006 05:31

can confirm the above. it has an off-label use for the treatment of bipolar manifesting as anxiety with depression. it supposes that anxiety is actually a form of mania.

i've never used it, but have seen it work remarkably well in others. totally inhibits the effects of the first two substances in the above list.

**Kris Kristofferson** · 07-01-2006 00:20

i dont know anything about abilify specifically, but if its anti-psychotic, you can forget about getting high. forget, also, about feeling much of anything.
that is, of course, ASSUMING its anything like the other anti psychotics, all of which i have been on at one time or another.
i have a sneeky feeling ive just made an ass out of myself

**blase deviant** · 02-05-2007 23:21

...ketamine, cocaine, opiates?

Or is it just me?

I'm thinking of switching to Risperdal or something...

**DopaMan** · 02-05-2007 23:56

Since all drugs of abuse cause an increase in dopamine somewhere along the lines, I'm sure that this drug will cause a decrease in enjoyment of all drugs. Abilify is a unique drug (as far as on the marketr anti-psychs go) which is a partial agonist at the D2 (which makes me think it might be slightly psychoactive (not exactly recreational though)).

If you are bipolar or schizophrenic you should consider cutting back on poly drug abuse as it may worsen your symptoms. Just a thought.

**Retrospect** · 23-11-2008 05:01

Originally Posted by DopaMan

Since all drugs of abuse cause an increase in dopamine somewhere along the lines, I'm sure that this drug will cause a decrease in enjoyment of all drugs. Abilify is a unique drug (as far as on the marketr anti-psychs go) which is a partial agonist at the D2 (which makes me think it might be slightly psychoactive (not exactly recreational though)).

If you are bipolar or schizophrenic you should consider cutting back on poly drug abuse as it may worsen your symptoms. Just a thought.

Nicely put.

**Retrospect** · 23-11-2008 05:07

^^ lol to that..

I haven't really searched around to much, I just took an interest in it.. & doesn't seem like many people know a whole lot about it.

**Hammilton** · 23-11-2008 05:12

lazarus...

**Frank Lucas** · 23-11-2008 05:32

It's a 5-HT2A antagonist so that would mute the effects of most psychedelics. It binds to the serotonin transporter, so that would mute the effects of MDMA. Abilify is a partial agonist at the dopamine D2 receptor, and since cocaine works by inhibiting the reuptake pumps of DA, NE, and 5-HT almost equally, I think cocaine would still work, but with less euphoria. Meth would probably still work too for the most part.

EDIT:
OMG this is an old thread...

**Retrospect** · 23-11-2008 05:46

lol yea exactly.. ^
Old thread.. I was just going through some shit on the search engine.. and came across a couple of these threads that I took interest in.. but seemed to have not turned up anything really interesting all at the same time.. or to helpful.. lol.. i guess.. so w/ that said.. 'bump'.

**Hammilton** · 23-11-2008 05:48

Why do you say it binds to SERT? I don't see this is true, but I'm not sure.

**Frank Lucas** · 23-11-2008 07:00

Here a few references. It's said to bind with moderate affinity - I'm not sure just how significant the effect is at normal theraputic doses as it is sometimes augmented with an SSRI anyway...

http://ajp.psychiatryonline.org/cgi/...l/163/6/1112-a
http://www.umm.edu/altmed/drugs/aripiprazole-008613.htm

**djsim** · 23-11-2008 07:05

Since all drugs of abuse cause an increase in dopamine somewhere along the lines, I'm sure that this drug will cause a decrease in enjoyment of all drugs. Abilify is a unique drug (as far as on the marketr anti-psychs go) which is a partial agonist at the D2 (which makes me think it might be slightly psychoactive (not exactly recreational though)).

Actually I've heard its alot more complicated than that. I had a lecture this semester that went into how its not as simple as saying agonist + receptor = response. In fact, different agonists can bind to the same receptor and each cause a different intracellular response. This would explain incomplete cross-tolerance amonst opiates amongst other things. This is never the best source but it gives you a good idea of what I'm talking about LINK

If you are bipolar or schizophrenic you should consider cutting back on poly drug abuse as it may worsen your symptoms. Just a thought

Well put

**Kore** · 23-11-2008 07:14

I was on Abilify for about 8 months. It completely killed the mental effects of shrooms and acid (both taken in large quantities)--I only got a weird body feeling on the shrooms, and jitteriness on acid. I'm guessing it would do the same for serotonergic psychedelics, you'd get the physical effects but not the mental ones.

**djsim** · 23-11-2008 07:25

I've just realised thse threads are like 2 years old :/
Nothing wrong with bringing up an old thead but if you do so it should be to ask a question rather than trying to scatter bump a bunch of old topics

**djsim** · 23-11-2008 07:30

Originally Posted by Frank Lucas

Here a few references. It's said to bind with moderate affinity - I'm not sure just how significant the effect is at normal theraputic doses as it is sometimes augmented with an SSRI anyway...

http://ajp.psychiatryonline.org/cgi/...l/163/6/1112-a
http://www.umm.edu/altmed/drugs/aripiprazole-008613.htm

Intersting... I wasn't aware antipsychotics effected the serotonin systems

**Mr Blonde** · 23-11-2008 07:34

Originally Posted by Dopaman

which is a partial agonist at the D2 (which makes me think it might be slightly psychoactive (not exactly recreational though)).

Expanding on what djsim said, it should also be noted that a lot of dopamine agonists tend to cause nausea and not have much recreational value. Ipecac comes to mind.

Yeah I know this is a dead thread.

**Captain.Heroin** · 23-11-2008 12:27

I had not heard of this antipsychotic medication, thanks for the news. Even if it is 2 years old...

**BingeBoy** · 23-11-2008 18:48

merging this into the other abilify interactions thread

**Scarletta** · 05-12-2008 19:10

It appears that at certain doses, Abilify actually increases the euphoria and other subjective effects of both methamphetamine and cocaine:

http://journals.cambridge.org/action...ne&aid=2539236

http://www.informaworld.com/smpp/con...l~jumptype=rss

From personal experience, having been on both Abilify and Adderall, I thought that Abilify was blocking the effects of the Adderall. But I was only on 5 mg of Abilify. I also don't know how much of this is just perception rather than reality. Like a placebo effect.

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