Cayenne Pepper - Vasoconstriction Miracle

[fluffybudzz]

Cayenne Pepper supposedly has vasodilator properties, and when used after a stim it gets rid of all vasoconstriction.

I posted on here a while ago mentioning it in the 'Vasoconstriction' thread, but have only just had the chance to try it.

Had a mephedrone night last night racked only a gram though. But, as always there was some severe vasoconstriction at the tail end of the night.

I made a strawberry smoothie for breakfast, and mixed in one tbsp of ground cayenne pepper.

Within 20 minutes all vasoconstriction was gone. This is a godsend.

If anyone has any scientific knowledge of why cayenne pepper does this I would love to know.

Cheers

[amapola]

http://en.wikipedia.org/wiki/Capsaicin

http://www.ncbi.nlm.nih.gov/pubmed/15320697

Capsaicin (8-methyl-N-vannillyl-6-nonenamide), via binding to the vanilloid receptor subtype 1 (VR1), stimulates a subpopulation of primary afferent neurons that project to cardiovascular and renal tissues. These capsaicin-sensitive primary afferent neurons are not only involved in the perception of somatic and visceral pain, but also have a "sensory-effector" function. Regarding the latter, these neurons release stored neuropeptides through a calcium-dependent mechanism via the binding of capsaicin to the VR1. A subset of capsaicin-sensitive sensory nerves contains calcitonin gene-related peptide (CGRP) and substance P (SP). These sensory neuropeptides are potent vasodilators and natriuretic/diuretic factors.
...

http://en.wikipedia.org/wiki/TRPV1
http://en.wikipedia.org/wiki/Calcito...elated_peptide
http://en.wikipedia.org/wiki/Substance_P

Or to put it a bit more simply...your body thinks it needs to cool down so it dilates your blood vessels in order to promote blood flow to the skin where it can shed heat like a car radiator.

[fluffybudzz]

http://en.wikipedia.org/wiki/Capsaicin

http://en.wikipedia.org/wiki/TRPV1
http://en.wikipedia.org/wiki/Calcito...elated_peptide
http://en.wikipedia.org/wiki/Substance_P

Or to put it a bit more simply...your body thinks it needs to cool down so it dilates your blood vessels in order to promote blood flow to the skin where it can shed heat like a car radiator.

cool thanks for that. Also I have used propranolol in the past to try and counter act vasoconstriction caused by methylone but had a very bad reaction (thought i was swelling up and thought my veins were gonna burst, nearly wound up in hospital but by the time we got there I had calmed down). Is there a difference between the vasodilator capabilities of propranolol and cayenne?

Some people have ridiculed cayenne pepper as a vasoconstriction cure, what other options are there?

[amapola]

Also I have used propranolol in the past to try and counter act vasoconstriction caused by methylone but had a very bad reaction (thought i was swelling up and thought my veins were gonna burst, nearly wound up in hospital but by the time we got there I had calmed down). Is there a difference between the vasodilator capabilities of propranolol and cayenne?

Propranolol is a beta blocker. It inhibits epinephrine and norepinephrine from working at the beta adrenergic receptors. By blocking beta you lower your cardiac output and thereby lower your blood pressure, but I don't think that helps with vasodilation at all. In fact due to excess adrenaline then hitting your alpha receptors it might trigger constriction of your blood vessels if anything.
http://en.wikipedia.org/wiki/Adrenergic_receptor

[PROZ4C]

Or to put it a bit more simply...your body thinks it needs to cool down so it dilates your blood vessels in order to promote blood flow to the skin where it can shed heat like a car radiator.

amazing

I must buy some Cayenne Pepper, I think they have capsules of it at the local supplement store.

[olab7]

how much do you think would be good with a glass of water?

[MrRoot]

Go buy some pepper spray if you can get it where you live. You had to do a one press on it each day to prevent it clogging so that it works when you need it for self defence so you can use it to flavor your food that way. And if you buy the potent ones you really get very good chili taste for example your pizza or kebab.

I used to do it while I worked for army.

[fluffybudzz]

I would say throw in like maybe a tea spoons worth. or maybe 3 quarters of a teaspoon.

I think I might start using this in winter, cos in England the weather is fucking miserably cold and cayenne literally makes you feel so nice and warm. good for people with clammy hands and bad circulation i think.

lol @mrroot. i prefer cayenne pepper tho. bit less of a body load lol

[SPC123]

We are only beginning to understand the effects of capsaicin on the body. Still there are several capsaicin based drugs currently on the market. I have some Zostix here which is a topical analgesic cream whose only active medical ingredient is capsaicin. Supposedly it helps with arthritis and neuralgias.

[ColtDan]

ive just bought some cayenne pepper. taken a few capsules, my chest feels all fuzzy and warm like when ive just done a shot of alcohol lol

[jasonmp321]

Go buy some pepper spray if you can get it where you live. You had to do a one press on it each day to prevent it clogging so that it works when you need it for self defence so you can use it to flavor your food that way. And if you buy the potent ones you really get very good chili taste for example your pizza or kebab.

I used to do it while I worked for army.

hold up hold up hold up. am i reading this correctly? Are you suggesting he spray pepper spray on his food, then eat it? This is one of THE WORST ideas i have EVER heard. LMAO, if you have a fucking EPIC HERO tolerance to capsaicain, i guess you could do this. But to mere mortals such as myself, i believe eating pepper spray laced food would be quite a painful fucking experience..... Jesus man, lol!

[ektamine]

Yup, found out about capsaicin about half way into my year long MDPV binge and it nearly saved my life.

It is very, very effective.

[after8mink]

Just chuckled to myself about the idea of pre-mixing mephedrone with cayenne pepper. I bet some would still snort it...

Any idea how long the effects of the capsaicin last for?

[Transform]

To dig this up, what sort of doses are people using? 500mg enough or is more required?

[ColtDan]

i usually take 2 500mg caps at least. dunno if its worked or not in the past, haven't noticed much

[Transform]

I would think the male genetalia would be the best indicator, since it's a pretty sure sign that there's vasoconstriction, even when it's only slight.

Upon further searching, it looks like this is only a local effect where it is applied to the skin, I can't find any evidence of it being used orally.