I have never experienced a psychotic reaction before and I have no history of any mental illness. But yesterday in hospital the doctor gave me a high dose of intravenous antipsychotic named Stemetil (prochlorperazine) which is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo as I had been vomiting all day.
About 30 minutes later I developed a sudden impending sense of doom unlike anything I have ever had before, it was an overwhelming feeling of restlesness and agitation. I became so uncomfortable lying in the narrow hospital bed in that cold room with an iv drip in one arm and a blood pressure monitor in the other and a heart rate monitor attached to my chest. I just couldnt sit still or get comfortable no matter what I did, I was like a dog circling its bed just before laying down. I began to twicth and move around in bed trying to find some peace but it got worse and worse and worse, I began to eperience a mixture of Dystona and restless leg syndrome and then I screamed and then next I did the most out of character thing for me...I just ripped off all the cables out of my chest and arms, the alarm went off and the doctor came into see what was going on.
I tried to explain to him I had a very severe restless, uncomfortable, agitated feeling and I just had of get ut of there real quick and go home. Luckly he let me go but when I stood up I could barely walk, I felt drunk and detached from reality. I asked the dctor if he had put anything else in my iv drip besides prochlorperazine and sodium chloride but he said I was probably just feeling tired.
Driving home was a challange, I just could't stop moving in my car seat from all the twitching and severe restless body aches like when you get the flue. I found myself screaming in frustration all the way home and wondering if I would ever be normal again as I felt mentally and phyically unstable and weird and my eyes were flickering like crazy and effecting my vision. I've slept on it since and I feel normal again except for some twitching and restless legs but I am still confused how I got all messed up in the first place, can anyone explain if prochlorperazine can cause such a reaction? Thanks.
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Last edited by effie; 13-01-2012 at 06:59.
- Join Date
- Jun 2010
Ive been taking antipstchotics for about a yeah but never have had that reaction.
ive never heard of the one he gave u.
but when ive taken seroquel befre expecially when i first tried it it made my vision go a but weird when it kicked but.
u may have had an allergic or at may be that type of AP
why on earth would they give u an AP?
dont worry about it now as long as they're not forcing u to continue taking it because most APs arnt to bad. i havnt had any concerns with them. think they are making me put on weight though. ive gained like 5kg over the last 12 months I think
That kind of reaction is called akathisia. Antipsychotics sometimes cause it and in worst cases it can last very long even after the medication is discontinued.
Thanks for the reply.
Anon54, they gave me prochlorperazine because its also used in the treatment of nausea, vomiting and vertigo. Because I was throwing up they gave it to me as an IV.
Polymath, thanks for your help, I looked up akathisia and the symptoms fit exactly with what I had. I am annoyed that I am still experiencing some of its symptoms even 12 hours later. Do you know any way I can reverse its effects or take anything that might help relieve it ? I am really hurting from all aches, spasms and movements in my body
It will probably go away soon, but if it doesn't you should talk to a doctor and they will probably give you beta-blockers for the symptoms. Benzos help too.
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- Dec 2010
I had a similiar reaction to haloperidol (Haldol) when I was trying to find something to knock me out during opi wds. What a fucking mistake! haha. Felt my muscle's begin to tense up and become very stiff. I felt like I couldn't stop moving (major RLS) and I started to feel a sense of of derealization and panic. I had to load up on my diazepam to stop the twitching, stiff muscles and the rising anxiety. I'll never put that drug in my system again after that expirience. When insomnia is an issue I'm going to stick to sedative antihistamines or Seroquel (which has never caused me akathisia), but preferably benzos.
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- Jun 2010
Anti-psychotics have cause these effects for me as well. Dysphoria and akathisia are quite common among some of the anti-psychotics, some aren't as bad. Taking them orally is less unpleasant than IV or IM IME.
Yeah, anxiety can be caused by anti-psychotics. Sometimes rapid heartbeat will send you going apeshit... Especially while you are trying to go to sleep.
I never used any anti-psychotic ever again after seroquel. It pretty evil to me that anyone besides complete and udder maniacs get put on major tranquilizers.
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- Jun 2010
I just wanted to add that anti-psychotics are indeed particularly noxious, dangerous, and unpleasant drugs that in my opinion have very limited use in medicine. Some are worthless because there are better ones available for whatever needs to be treated. Long-term use of anti-psychotics is particularly dangerous and risky due to the possibility of life-long side effects. Like I said there are certain conditions that an anti-psychotic can help, but they are extremely overused in medicine today.
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- May 2010
- santa rosa, CA
anti psychotics stop psychotic episodes
^ They do. But as others have said, they also have a range of unpleasant side effects. It is a matter of balancing the benefits with the risks. It always makes me nervous when I see people casually using handfuls of Seroquel to sleep, yet antipsychotics definitely do have their place and the newer "atypical" ones have fewer of the movement side effects that the older ones such as prochlorperazine and haloperidol do (although they have their own side effects..)
They definitely have their place, when used properly (prochlorperazine is often a good treatment for vomiting and vertigo, as well as being an antipsychotic) and not everyone gets akathisia (or acute dystonia, a more extreme reaction) but as you have found out AP, when you do get the side effects they are not much fun! As polymath said, they should subside but if not I would go and see your GP.
Thank you for all the great advice. Does anyone know of any anti nausea medication that is better tolerated and not also an antipsychotic drug?
What I need is two types of medication, one to stop the nausea and vomiting and the other to help speed up the emptying of my stomach. The whole reason why I am vomiting is because I have a Gastroparesis, a condition that reduces the ability of the stomach to empty its contents, so the food ends up going bad spoiling in my gut and causing vomiting. I have a damaged Autonomic Nervous System (Dysautonomia) so it also effects my digestive tract by impairing function and lately it has gotten worse.
The same Doctor who gave me Stemetil (prochlorperazine) aso prescribed me MAXOLON (Metoclopramide hydrochloride) which is used to encourage normal passage of food through the stomach and intestines but because I already had a bad reaction to prochlorperazine I am also reluctant to start on the Maxalon. Does anyone know if Metoclopramide is also likly to cause the same type of reaction? If so is there a safer alternative? Is Cannabis able to help with nausea and increase the gut to empty and allow things to move along?
^ Metoclopramide is far less likely than prochlorperazine to give you akathisia, although it does still have weak antipsychotic proerties. If I were you I would still try it, as all the prokinetic antiemetics I know also have weak antipsychotic properties.. domperidone is another one.. and just because you have had a bad experience with one doesn't necessarily mean you will have a bad one with another. I understand your reluctance though!
Procyclidine can help if you get bad symptoms again - I'd head to your ER where they can administer that.
Most other antiemetics work on the vomiting centre in the brain rather than on speeding up gastric motility...
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- Oct 2011
never had the twitchy side effect you described, though I was on seroquel for two years at a top dose of 800mg and I'll tell you it was hell. At that dose it hit me like a truck and, though I'd pass out in a few minutes, I suffered really nasty and acute panic during that time.
I'm guessing the doses of the medicine you were given are lower when used for nausea than acute psychosis. I'm surprised though that the doc didn't warn you that it could have that kind of effect. Most psychoactive drug side effects are not nearly as bad when you expect them. Otherwise you think something is legitimately wrong and it's not just a pill in your system, meh, irresponsible doctor if you ask me.
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- Jun 2010
I'm sorry, from my experience, metoclopramide was the devil when it came to dysphoria and akithisia, esp. when given IV.
^ everyone is different. there is less chance with metoclopramide but the chance is still there. i've had both and been fine - but that's anecdotal, as is people's bad experiences. the risk is there - statistically it's low, but it is there...
I wouldn't imagine being under high influence of an anti-psychotic could, but I do know that during the same time period that I was taking Seroquel I did in fact have an INSANE psychotic reaction that basically made people (understandably) label me the crazy kid of the neighborhood.
Antipsychotics are in my opinion one of the worst class of substances in existence, let alone that BIG Pharma has come up with; I mean seriously, the shit is so fucking stifling and really only aught to be used under an extreme emergency--not for daily use. I could honestly see people going on murdering rampages spurred by the deeply depressive feeling of taking an anti-psychotic regularly.
Thanks everyone for all the helpful information. The first time I began to feel the weird effects of the prochlorperazine I didn't know what to make of it, I kept telling myself it was only stemetil used for nauseau and it could not have possibly been responsible for the way I was feeling, i tried to blame it on lack of sleep and food but then i relaized i've been deprived of those things countless times before and still not felt like that.
I began to question if the doctor had put anything else in my drip but the worse i got the more i started to realise it was definetly one of the ingredients in the drip. Now you guys have confirmed my concerns as being the anti-psychotics and I thank you all for that. I seem to have fully recovered from the effects now and its one thing I will never allow in my system again.
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- Nov 2010
Hey buddy - sorry to hear about the crazy reaction.
That really sucks.
The Stemetil is a D2 antagonist - or a dopamine blocker.
The Maxolon is likely to produce some negative effects as well because it is also a D2 antagonist.
But it is also a 5ht3 antagonist, which is the serotonin receptor directly responsible for nausea.
The Maxolon is very unlikely to produce such a severe reaction - because oral administration SLOOOWS down the metabolism of the drug. Any injected drug will have a much more pronounced effect. So it is possible that a more controlled intake of stemetil would not have caused such a freakout. But considering your history, I suspect it would have been quite unpleasant no matter what.
Just to let you know, I have experienced what I would consider mild 'gastroparesis' throughout the last year.
Serotonin controls the contraction of smooth muscle around the intestines - this is its primary function.
And the hypothalamus, which is hyper-innervated during recovery from toxic MDMA exposure, is the control center for the release of digestive enzymes.
It is also the control center for the entire endocrine and adrenal system.
The relationship between the hypothalamus and serotonin is what provides emotion to thought.
As unpleasant as your reactions to drugs are, I consider them a sign of a very long-term recovery process.
Although it might be very uncomfortable or frightening to experience, I encourage you to embrace such experiences as they may have the potential to restore some level of function.
Anxiety, after all, is a prominent feature of recovery among most MDMA users.
The ongoing fevers that you experience across a variety of drugs is evidence enough.
Altered thermal-regulation has been documented in former MDMA users.
I have experienced quite a few mild fevers in the past few months.
They feel a bit like catching a virus...
But I consider them a good sign.
Strange that they did not occur more during the early part of my recovery.
It didn't set in until later on, except for the first few nights.
Maybe there is hope for you yet.
I had another episode of Gastroperesis (delayed gastric emptying of food) again today. This is going to sound weird but I think I found the reason why its occuring....Grapefruitjuice.
That was the exact trigger last time but I didn't know until I repeated the mistake to be certain.
How is this even possible? So I took the Grapefruit Juice and then took my Oxycodone, then waited the usual 40 minutes for it to kick in...nothing, 1 hour later still nothing, waited 2 hours...nothing then 4 hours later...BOOM! massive Oxycodone reaction. This is exactly what happened a few days ago when I developed Gastroperesis after taking Grapefuitjuice and found my oyycodone delayed by 3 hours.
Grapefruitjuice really does some weird things to me, one time it caused me to develop bradycardia from oxycodone so whenver I took the GFJ and Oxy together it caused my heart rate to fall into the low 40 bpms, that type of reaction occured everytime for about a month and then eventually resolved itself. Another time I took GFJ it made the Oxycodone last for 8 hours instead of wearing off in 3 hours and this went on for about 3 weeks everytime i took them together. One other time it had no effect at all on the oxycodone not even potentiation...and now this week its causing a delayed effect in my digestion (gastropereisis) and making food and medication sit in my stomach for hours and causing it to spoil, ferment and make me vomit and this phase will probably last for a few weeks before it resolves as well just like all the previous unexplained Grapefruit mysteries. Everytime I take grapefruitjuice with oxycodone its like rolling the dice, i dont know what the hell its going to come up with next. Can anyone explain why?
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- Nov 2010
Grapefruit juice is well-known to interact with different drugs, especially stronger opiates like oxy.
Grapefruit juice is a potent inhibitor of the cytochrome P450 CYP3A4 enzyme.
Anything that inhibits the P450s can prolong or increase the effects of a drug.
And oxycodone is known to cause digestive problems like nausea and constipation with continued use!
But gastroparesis onset directly linked to grapefruit....twice.
That is rather severe, so I would assume that any inhibition of P450 enzymes could cause major metabolic changes in your system.
Hydrocodone is a substrate for both CYP3A4 and CYP2D6 enzymes, meaning they react to form a different compound (morphine).
But you are inhibiting the CYP3A4 with grapefruit, causing its effect to slow down.
Oxycodone is mainly metabolized by CYP2D6, so I don't know if there is any overlap.
Enzyme interactions are damned complex and understanding them won't really explain gastroparesis.
Maybe a little nausea and cramping, which is fairly common in some people.
But not hours of food sitting along with a lack of drug activity, then a sudden onset.
I should mention that a much milder version of those events has occurred to me with hydrocodone.
I find myself feeling almost nothing from it, until suddenly my gut starts moving.
It is the serotonin activity involved in digestion that exposes some of the brain pathways to the drug.
On nights when I am completely empty, there might not be ANY effect no matter how long I wait.
If I am too full, the effect is delayed until gastric movement occurs.
I literally have to time it just right to achieve the desired effect, and movement in my intestines is the key.
Its kinda like first and second-pass metabolism with alcohol.
A portion of it is absorbed in the mouth and stomach, but when the stomach empties into the small intestines, there is a sudden increase in blood alcohol content.
This is a big cause of alcohol poisoning, because people are not aware just how much they have had if their stomachs are full.
I have come to believe that there is much more than first and second pass.
I think that each section of the intestines represents its own metabolic potential, exposing more of the brain to the contents of the bloodstream.
Serotonin, which drives digestion, also influences blood distribution throughout the brain!
I imagine that this is a seamless event for most people, undetectable and uninteresting. The gut is firmly bound to the brain.
Only on night of heavy drinking could someone relate to the idea that the further down the gut it travels, the more regions of the brain will feel the effects.
Even all the way down to the large intestines!
In fact, the lower it goes the more euphoric the experience.
The seamless nature of the brain-gut circuitry has been interrupted in both of us.
Whatever the contents of our bloodstreams, be it alcohol or opiates, it does not effect our brains the same way.
Even smoking weed seems to rely on the movement down below!
Some days it feels normal, some days it does NOT.
I do not really believe that each segment of intestines further absorbs the drug...
Many drugs are easily absorbed in the first section of small intestine and stomach.
And the similar effect with smoking pretty much rules that out.
It is the smooth uniform contraction of the GI that allows the brain even, uninterrupted access to ANY drug or drug metabolite in the bloodstream.
I hope this is making sense to you.
Think of your gut like an accordian that is being constantly tugged on.
Sometimes it is not a gentle tug, but a pull or push.
The rhythm of this instrument is critical to the right notes being played in the mind.
It turns out that digestion, along with a number of emotions, are the result of a carefully tuned symphony of events.
And I never would have understood this so well before.
That is the best explanation I can offer you buddy.
Your accordian, your symphony, is out of sync.
In general, I recommend against regular drug use even opiates.
If I understand your other posts correctly, you often fail to feel any euphoric effects in the first place.
And you are tinkering with your metabolic enzymes...
If you didn't take oxycodone, you wouldn't have some of these problems.
But my guess would be that you DO feel some reward from taking it, or you just wouldn't be interested.
Combating gastroparesis with medication like D2 antagonists sounds like a very temporary solution to me - treating the symptom not the cause.
Medicine is capable doing more harm than good, especially when it come to anti-psychotics.
The cause is your damaged serotonin transmission.
And there is no drug to correct this, yet.
But I HIGHLY recommend exercise when you have a full stomach.
Healthy diet with lots of fiber and fluids should be a daily part of your life!
But if you stray from this healthy diet for even a day, I firmly believe that getting your BLOOD PUMPING will combat the lack of digestive ability.
It will push your symphony back into sync.
Anytime I have a bad feeling in my gut, especially when it effects my mood...I do pushups on the spot.
Especially if I really don't want to.
It is when I am the least comfortable that it makes the most difference.
I do quite a few - up to 300 in a night!
But it takes a lot to get me winded now.
The whole point is to do something that makes your heart pump faster.
This will increase enzyme activity, metabolism throughout the body, and encourage gastric emptying.
And it increases plasticity in the serotonin nerves in your brain!
Exercise is about the ONLY treatment that exists for MDMA related serotonin toxicity.
I wish I had more advice for you, but I don't.
Maybe a mild amphetamine like selegeline would help you.
Maybe low-dose ketamine.
I have considered both.
I will stick to my daily exercise regimen for now.
I really can't imagine what level of function I would be at without it.
You should be exercising every single day.
First Bad Comedown, Thanks so much for all your help. I am glad you posted as you seem to know a lot.
You found my comment about not feeling anything euphoric from oxycodone and you made an observant judgement saying "you DO feel some reward from taking it, or you just wouldn't be interested"...
It is true I get no euphoric feeling at all, if anything I get the opposite by often feeling dysphoria from Oxycodone but I will be honest, the only reason I keep going back to it is because Oxycodone helps me get my mind off the physical and emotional pain, even having an adverse reaction to it sometimes makes me forget the pain and as crazy as it sounds I have come to look forward to the adverse reactions, i know i must be one sick puppy ey? the other reason i take Oxycodone is because it makes sex last longer both through its depressant effect and its adverse reactions by distrupting my vitals, which is why I keep coming back to it, otherwise there is absoloutely no other benefit for me from Oxycodone or any other pain killer.
I will definetly take up your advice on excercising, you are too right about that, in the past I have seen its benefits and it has even stabilised a lot of my symptoms, thanks for such an excellent advice.
I did a bit of research on the topic of Grapefruit Juice and Gastric emptying and right away my search results found several articles stating that the potentiation effects of Grapefruitjuice are not only due to inhibition and effect on enzyme activity but also due to its effect of slowing of gastric emptying.
This study shows that grapefruit juice interferes with the metabolism of NIF by inhibiting NIF metabolism and slowing down the rate of gastric emptying. This study also confirms that the metabolic inhibition is not a first pass effect, but is a secondary oxidative step.
http://www.ncbi.nlm.nih.gov/pubmed/15811168the delay in nifedipine absorption by GJC or OJC results from delayed gastric emptying.
http://www.ncbi.nlm.nih.gov/pubmed/9570001Grapefruit juice or grapefruit: significantly increases plasma levels of buspirone. The possible mechanism of this interaction caused by grapefruit juice is delayed gastric emptying and inhibition of cytochrome P450 3A4.
http://www.sideeffectsofmedication.c...-side-effects/As a result of delayed gastric emptying, grapefruit and pineapple juices may moderate sharp increases in postprandial plasma TAG concentrations accompanying peak digestion and absorption.
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- Nov 2010
Opiates are agonists at dopamine receptors.
And you are living with hindered dopamine transmission because of the serotonin damage.
Although the typical feelings of pleasure may be absent, the uncomfortable feelings may be a result of dopamine release which temporarily makes you feel just a little better.
You are pushing back against the onslaught of serotonin!
Exercise is the best way to do this, of course.
Aside from BDNF induced serotonin growth...
It both releases dopamine and restores adrenal function.
Healthy adrenals mean lower serotonin...
I'm glad to hear your response.
Push yourself for a solid 20minutes a day, 5 days in a row.
Then come back and tell me how you feel on day 6 and 7.
I really want to know.
Great studies you found on Grapefruit.
I never knew...
I am normally cautious about recommending drugs to people....but I will make an exception for you.
Since you like opiates, there is an astonishing option available that provides a very unique and LONG lasting opiate high.
Poppy is of course the flower that all opiates, including oxycodone, come from.
What is surprising is that poppy pods are available for purchase online legally, as decorative items.
This is an interesting loophole and it results from the fact that poppy grows easily across North America - and there is nothing the government can do to stop it.
Owning a poppy plant or purchasing the dried pods is necessarily legal.
Only when you begin processing the pods into a useable form have you committed a crime.
Of course having posted online about your knowledge of pods recreational value can be used as incriminating evidence...
All of this aside, poppy contains many alkaloids that oxycodone does not.
The best pods are called tazmanian and they contain a much higher level of morphine.
This is the species of poppy that the world's pharmaceutical supply comes from.
I recommend pods to you for a simple reason - they are stronger than people assume and the buzz lasts many hours.
Even heroin addicts are surprise by their potency.
It is not the increased dosage I am recommending for you, it is the increased alkaloid profile.
Perhaps with the right mixture, you would actually enjoy the feeling.
But I must warn you - they are STRONG.
Many posts can be found of people that underestimate the strength.
Some idiots will grind up five whole pods their first time.
Then they claim near-death experiences!
Even a whole pod is a HUGE dose for me.
I find that about a fourth of one pod will last me many blissful hours.
And it is indeed a very deep, blissful body high.
Unlike pills, which normally hit me within an hour, pods take at least two hours to start.
And they do not peak until FOUR hours!
This is a big cause for retarded dosing - people don't feel anything and just take more.
Another warning - pods create cramps in normal people.
And nausea in others.
I find the stomach discomfort to be tolerable, but strong.
And it is also stimulating like a cup of strong coffee at some points.
It is not the most comfortable opiate high, compared to hydrocodone or oxy.
But considering tramadol makes me fucking freak out, I consider mild discomfort from poppy to be well worth the intense euphoric buzz they provide.
Since your system is so different and responds to drugs with lots of anxiety - I highly recommend you start with tiny doses.
If it turns out to be really uncomfortable for you, it will last much longer than you want it to.
But there is a chance it will turn out to be the best opiate buzz you have felt in a long time.
I highly recommend it, but stay AWAY from grapefruit on that stuff.
And whatever you do, do NOT make a habit of taking it.
I have read heroin addicts that claim poppy withdrawal is WORSE than heroin!
The same varied alkaloid content that makes it so satisfying also makes it more addictive and difficult to stop taking.
People have really fucked themselves up by taking the stuff weeks in a row.
I hope you try it and enjoy it - responsibly.
Especially after a week of exercise.
Let me know.
We don't usually have long discussion threads in BDD but this one is clearly useful (and interesting!) so I'm not closing it - I am however going to change the title to attempt to reflect the change in direction of the thread, hehe. Hope that is okay
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- Nov 2010
For such an awesome thread, Altered Perception should tell his story.
Remind people about what happened to you.